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If performance is abysmal on a simple query, check for missing or corrupted MySQL indexes that may cause the query engine to do full table scans.

 TCMalloc and MySQL

Interesting GitHub blog post (https://github.com/blog/1422-tcmalloc-and-mysql) describing debugging MySQL performance issues, and using tools like the open source Percona Toolkit and the Google-contributed TCMalloc from gperftools.