| Institution | Repository | Application Framework | Status | Contact |
|---|
| Amherst College | Amherst College Digital Collections | Custom, Hydra | Development | |
| Arizona State University | Research Repository of the Nexus Lab | Hydra | Development | |
| Art Institute of Chicago | LAKE | Custom, Hydra | Development | |
| Chemical Heritage Foundation | | Hydra | Development | |
| Cleveland Museum of Art | CMA Archives | Hydra | Development | |
| El Colegio de México (COLMEX) |
| Hydra | Development |
|
| College of the Holy Cross | Digital Transgender Archive | Hydra | Development | |
| Columbia University | Academic Commons | Hydra | Development | |
| Cornell University | AgriKnowledge | Hydra | Production | |
| Duke University | | Hydra | Development | |
| Durham University | Collections | Hydra | Development | |
| George Washington University | GW ScholarSpace | Hydra | Development | |
| Indiana University | Pages Online | Hydra | Production | |
| Indiana University | Imago | Hydra | Production | |
| Indiana University | Avalon 6.0 | Hydra | Development (w/ Northwestern) | |
| Indiana University | PHYDO (HydraDAM2) | Hydra | Development (w/ WGBH) | |
| Lafayette College | LafayettePreserve | Hydra (Sufia 7.x) | Development/Production (Access-Restricted) | |
| LYRASIS | DTS Hosted Repositories | Islandora | Development | Jonathan Green |
| Metropolitan New York Library Council | DCMNY | Islandora Custom | Development | Diego Pino Navarro |
| Northwestern University Galter Health Sciences Library | Digital Repository | Hydra | Development | |
| Ohio State University | Digital Collections | Hydra (Sufia 7.0, Fedora 4.7.1) | Production | Russell Schelby |
| Penn State University | ArchiveSphere | Hydra | Development | |
| Penn State University | ScholarSphere | Hydra | Production | |
| Princeton University Library | Plum (Workflow, Digital Collections) | Hydra | Development | |
| Royal Library of Denmark | Danish Letters | Hydra | Production | |
| Stanford University | | Hydra | Development | |
Staatsbibliothek zu Berlin | Prussian Judgments (1880-1945) | Hydra | Production | |
| Syracuse University | | | Development | |
| University of Alberta | Education & Research Archive | Hydra | Production | |
| University of California, San Diego | Digital Collections | Hydra | Development | |
| University of Cincinnati | | Hydra | Development | |
| University of Manitoba |
| Islandora | Development | Jared Whiklo |
| University of Maryland | Digital Collections and General Digital Repository | Custom, Hydra | Development | Joshua Westgard |
| University of Michigan | Deep Blue Data | Hydra | Production | |
| University of Michigan | Fulcrum | Hydra | Production | |
| University of Michigan - ICPSR | DataLumos | Custom | Production | |
| University of Michigan - ICPSR | openICPSR | Custom | Production | |
| University of North Carolina Chapel Hill | Carolina Digital Repository | Custom | Development | |
| University of New South Wales | ResData | Custom | Development | |
| University of Pennsylvania | Colenda | Custom, Hydra | Development | |
| University of Saskatchewan |
| Islandora | Development |
|
| University of Virginia | | Custom, Hydra | Development | |
| University of Washington | DRUW | Hydra | Development | |
| University of York | Archbishops' Registers | Hydra | Production | |
| Virginia Tech | DataRepo | Hydra | Development | |
| Washington University in Saint Louis | Repository | Hydra | Production | Mark Sellan |
| WGBH | HydraDAM | Hydra | Development | |
| Yale University | | Hydra | Development | |
| York University | York University Digital Library | Islandora | Development | |
| | Digital Repository of Ireland | Custom | Development | |
| | Oregon Digital | Hydra | Development | |